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dc.contributor.authorGrønlien, Krister Gjestvang
dc.contributor.authorPedersen, Mona Elisabeth
dc.contributor.authorTønnesen, Hanne Hjorth
dc.date.accessioned2020-10-21T09:17:12Z
dc.date.available2020-10-21T09:17:12Z
dc.date.created2020-04-23T20:55:59Z
dc.date.issued2020
dc.identifier.citationInternational Journal of Biological Macromolecules. 2020, 156 394-402.
dc.identifier.issn0141-8130
dc.identifier.urihttps://hdl.handle.net/11250/2684105
dc.description.abstractNatural deep eutectic solvents (NADES) have previously shown antibacterial properties alone or in combination with photosensitizers and light. In this study, we investigated the behavior of the structural protein collagen in a NADES solution. A combination of collagen and NADES adds the unique wound healing properties of collagen to the potential antibacterial effect of the NADES. The behavior of collagen in a NADES composed of citric acid and xylitol and aqueous dilutions thereof was assessed by spectroscopic, calorimetric and viscosity methods. Collagen exhibited variable unfolding properties dependent on the type of material (telo- or atelocollagen) and degree of aqueous dilution of the NADES. The results indicated that both collagen types were susceptible to unfolding in undiluted NADES. Collagen dissolved in highly diluted NADES showed similar results to collagen dissolved in acetic acid (i.e., NADES network possibly maintained). Based on the ability to dissolve collagen while maintaining its structural properties, NADES is regarded as a potential excipient in collagen-based products. This is the first study describing the solubility and structural changes of an extracellular matrix protein in NADES.
dc.language.isoeng
dc.subjectRestråstoff
dc.subjectRest raw material
dc.subjectNatural deep eutectic solvent
dc.subjectNatural deep eutectic solvent
dc.subjectCollagen
dc.subjectCollagen
dc.titleA natural deep eutectic solvent (NADES) as potential excipient in collagen-based products
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber394-402
dc.source.volume156
dc.source.journalInternational Journal of Biological Macromolecules
dc.identifier.doi10.1016/j.ijbiomac.2020.04.026
dc.identifier.cristin1807766
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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